Professor Chris Shaw
King’s College, London
Identifying disease-causing genes and pathways for drug manipulation
Christopher Shaw is Professor of Neurology and Neurogenetics at King’s College London. His clinical training was conducted in New Zealand and in 1992 he came to Cambridge, UK on a Wellcome Trust Fellowship. In 1995 he moved to King’s College London and he runs a clinic for people with motor neuron disorders at King’s College Hospital. Over the past 15 years he has led an initiative to build the Maurice Wohl Clinical Neuroscience Institute, where he is the Director. He is also an Associate Director of the UK Dementia Research Institute.
Over the past 25 years his team have discovered many gene mutations that can cause MND. These genes are now tested in laboratories around the world. From these discoveries they have also developed a large number of stem cell and transgenic mouse models of disease that they have made freely available to other researchers internationally. Research on these models of MND have revealed important insights into disease mechanisms, identified novel therapeutic targets and new hits from drug screens. Their major focus for the future is to develop gene therapies using antisense oligonucleotides and adeno-associated viral gene vectors which will be the focus of todays lecture.